Supplement
Effectiveness scores 40 due to poor oral absorption of reduced glutathione—key RCTs (e.g., Witschi 1992) show no elevation in plasma GSH levels at 3g/day, undermining brain detox and neuroprotection claims despite theoretical benefits. Animal/in vitro studies support antioxidant roles, but human trials are small, inconsistent, and lack meta-analyses for longevity or neurodegeneration prevention. Liver benefits seen in one RCT (300mg/day improved enzymes in NAFLD), but doses match product minimal
Average (58/100) - Effectiveness scores 40 due to poor oral absorption of reduced glutathione—key RCTs (e.g., Witschi 1992) show no elevation in plasma GSH levels at 3g/day, undermining brain detox and neuroprotection claims despite theoretical benefits. Animal/in vitro studies support antioxidant roles, but human trials are small, inconsistent, and lack meta-analyses for longevity or neurodegeneration prevention. Liver benefits seen in one RCT (300mg/day improved enzymes in NAFLD), but doses match product minimally. Safety is near-perfect (98) as adverse events are negligible per PubMed reviews; FDA reports no recalls or warnings for this product/ingredient. Quality (65) reflects transparency but absence of third-party verification—BrainMD is reputable but unverified independently, reducing trust vs. certified competitors. Overall 58 (40*0.6 + 98*0.25 + 65*0.15) rates Average; opt for liposomal GSH or NAC (600-1200mg) for superior evidence and uptake.