Supplements
Effectiveness rated low due to strong preclinical GH-releasing data but absent human trials for primary claims (muscle gain, fat loss). Key studies: animal potency (PubMed 9849822, ED50 2-80 nmol/kg); human PK/PD (Springer 1999, GH peaks but short-lived); failed ileus RCT (PubMed 25331030, no efficacy). Safety penalized for FDA Category 2 status with death-linked AEs, no approval, and compounding recalls despite short-term tolerability. Quality low: no standardized testing, variable vendor purit
Avoid Ipamorelin due to insufficient clinical evidence for effectiveness in healthy adults and FDA-identified safety risks including serious adverse events. Short-term GH stimulation shown but no proven benefits for muscle/fat; long-term risks unknown. Safer alternatives like lifestyle or approved GH therapies preferred.