Supplements
Effectiveness rated low due to robust animal data (e.g., PubMed 9849822: GH Emax 65 ng/mL in swine; PubMed 10373343: dose-dependent bone growth 42-52 microm/day in rats at 18-450 mcg/day) but scant human evidence—no proven benefits beyond transient GH pulse (1999 trial) and failed ileus RCT (PubMed 25331030: no p<0.05 outcomes). Safety moderate from trial tolerability but penalized for FDA ban proposal (immunogenicity, no SC PK data, GH risks) and lack of long-term studies. Quality low: no third
Avoid Ipamorelin due to lack of FDA approval, limited human evidence beyond GH pulsatile release, and significant regulatory risks including proposed compounding ban. Safer approved GH therapies exist for deficiencies. Not recommended for supplements/muscle/anti-aging without medical supervision.