Supplements
NAD+ nasal spray scores low due to absence of human RCTs supporting claims, relying on one rat ischemia study (PubMed PMID 17127275) showing brain NAD+ increase at 10 mg/kg (~700 mg human equivalent), far exceeding typical 30-120 mg/day doses. Oral NMN boosts NAD+ (e.g., 300-900 mg/day in trials) but fails to improve muscle strength, insulin sensitivity, or aging markers in meta-analyses (Examine.com). Safety docked for FDA unapproved status (warning letter to AliveByNature for disease claims).
NAD+ nasal spray lacks human evidence for claimed benefits and is not FDA-approved. Opt for well-studied oral NMN/NR precursors instead. Avoid until clinical trials confirm efficacy.