Supplements
Chamomile-derived supplement for relaxation before sleep
Excellent (81/100) - Effectiveness scores 70 due to strong preclinical evidence (e.g., PubMed 38732259 on neuroinflammation reduction aiding sleep indirectly; PMC10929570 on NAD+/sleep pathways) but sparse human RCTs for pure apigenin at 50mg—mostly extrapolated from chamomile trials (e.g., 220-440mg chamomile yielding 2-10mg apigenin showing minor sleep improvements). Huberman's stack (50mg apigenin + magnesium/theanine) has anecdotal support from his protocols, but standalone efficacy lacks robust meta-analyses, capping score despite mechanistic plausibility. Safety is near-perfect (97) as a food-derived compound with no FDA flags or reported AEs at this dose, only theoretical interactions. Quality hits 100 via NSF certification, outperforming untested competitors. Overall 81 reflects premium quality/safety bolstering moderate evidence for sleep use.